Does GenF20 Plus Work? HGH Support Evidence Reviewed

What the Product Trial Found

The one product trial is Sonawane et al. (2015), a randomized, placebo-controlled study in India. Among 70 adults aged 35 to 65, some were assigned GenF20 Plus and the rest placebo for 12 weeks (two tablets and 2 mL of liquid under the tongue, twice a day), and 61 completed it. For all participants combined, IGF-1, a blood marker linked to growth hormone, climbed 13.46 ng/mL on GenF20 Plus and 6.35 ng/mL on placebo. The gap was not statistically significant.

The 28% rise that gets quoted so often comes from a later analysis, limited to participants aged 40 and over and adjusted for baseline differences. Placebo and GenF20 Plus did not differ significantly on body fat, lean mass, waist, memory, libido, energy or sleep. A contract research firm with outside financial support ran this small, exploratory trial, and nobody has independently repeated it.

The Limits of HGH Releasers

GenF20 Plus has no growth hormone in it. Mayo Clinic notes that research hasn't shown supplements that claim to raise HGH to work. The FTC stated in 2005 that it knew of no competent evidence for HGH pills or sprays raising growth hormone. For a comparison with prescription treatment, see HGH supplements vs HGH injections.

Main Ingredients (tablet, per serving)

• L-arginine 130 mg, which is a small fraction of the multi-gram doses used in arginine growth hormone research
• L-glutamine 115 mg, plus L-glycine, L-lysine and L-tyrosine at 100 mg each, all small amounts
• GABA 50 mg, which may lower blood pressure
• Animal-derived, so not vegetarian: bovine colostrum 50 mg, deer antler velvet 50 mg and anterior pituitary powder 30 mg
• Astragalus root extract 60 mg, with smaller amounts of other amino acids and chromium. The official site doesn't list the oral spray's ingredients

GenF20 Plus has a 67-day guarantee counted from delivery. Conditions apply: opened and unopened boxes must reach the warehouse within 67 days, and shipping isn't refunded. Who should avoid it is covered in our GenF20 Plus side effects guide.

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